RTOG 0937: Randomized Phase II Study Comparing Prophylactic Cranial Irradiation Alone to Prophylactic Cranial Irradiation and Consolidative Extra-Cranial Irradiation for Extensive Disease Small Cell Lung Cancer
Description of Research
The purpose of this study is to compare the effects, good and/or bad, of radiation given to the brain after chemotherapy with radiation to the brain, chest and up to 3 other sites that did not completely respond to treatment after chemotherapy to find out which is better. In this study, patients will get either radiation to the brain or radiation to the brain, chest, and other sites that did not completely respond to chemotherapy.
Jedidiah Monson, M.D.
Patients with extensive disease small cell lung cancer, excluding CNS metastases; patients must have had radiographic evidence of 1-3 extra-cranial metastatic lesions prior to platinum-based chemotherapy AND have had radiographic partial or complete response to chemotherapy in a minimum of one site of disease and no progression in any site.