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Clinical Trials

IRB Number   11013
Treatment   Breast Cancer
Trial Title   RTOG 0974 OR NSABP B-43: A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ (DCIS) Resected by Lumpectomy
Description of Research  

The purpose of this study is to compare the effects, good and/or bad, of radiation therapy with or without the addition of trastuzumab to find out which treatment is better. The drug trastuzumab is called a targeted therapy because it targets breast cancers that make too much of a protein called HER2. These cancers are called HER2-positive. Trastuzumab is approved by the FDA for the treatment of invasive HER2-positive breast cancer. Trastuzumab has not been approved as a treatment for DCIS breast cancer and is considered investigational in this study.

Principal Investigator   Jedidiah Monson, M.D.
Inclusion/Notes  

DCIS Resected by Lumpectomy, determined to be HER2- Positive by Central Testing.

Status   Open
Contact Name   Christyn Anderson, CCRC
Phone   (559) 450-7723
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