RTOG 0815: A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy with or without Short-Term Androgen Deprivation Therapy for Patients with Intermediate-Risk Prostate Cancer
Description of Research
The purpose of this study is to compare the effects of dose-escalated radiation therapy with or without hormone therapy on prostate cancer. Prior studies have suggested possible advantages to the administration of hormonal therapy with radiation. However, those studies were performed with radiation techniques that do not match those commonly used in clinical practice today (that is, dose-escalated radiotherapy). Therefore, we will be testing to see if similar benefits for hormonal therapy are seen when used with current radiation therapy techniques.
Jedidiah Monson, M.D.
Clinically localized, lymph node negative adenocarcinoma of the prostate diagnosed within 6 months* prior to registration at intermediate risk for recurrence as determined by harboring one or more of the following intermediate-risk features: Gleason Score 7; PSA >10 but ≤20; Clinical Stage T2b-T2c.