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Ewing sarcoma is a malignant (cancerous) bone tumor that affects children.
Ewing family of tumors; Primitive neuroectodermal tumors (PNET)
Ewing sarcoma can occur anytime during childhood and young adulthood. But it usually develops during puberty, when bones are growing rapidly. It is 10 times as common in Caucasian children as in African American, African, and Asian children.
The tumor often spreads (metastasizes) to the lungs and other bones. At the time of diagnosis, spread is seen in about one-third of children with Ewing sarcoma.
In rare cases, Ewing sarcoma occurs in adults.
There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor.
Children may also break a bone at the site of the tumor after a minor injury.
Fever may also be present.
If a tumor is suspected, tests to locate the primary tumor and any spread (metastasis) often include:
Treatment often includes a combination of:
The stress of illness can be eased by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.
How well a patient does depends on:
The best chance for cure is with a combination of treatments that includes chemotherapy plus radiation or surgery.
The treatments needed to fight this disease have many complications. Discuss these with your doctor.
Call your health care provider if your child has any of the symptoms of Ewing sarcoma. An early diagnosis can increase the possibility of a favorable outcome.
Anderson ME, Randall RL, Springfield DS, Gebhardt MC. Sarcomas of bone. In: Niederhuber JE, Armitage JO, Doroshow JH, et al., eds. Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2013:chap 92.
Cote GM, Choy E. Update in treatment and targets in Ewing sarcoma. Hematol Oncol Clin N Am. 2013;27:1007-1019.
National Cancer Institute: PDQ Ewing Sarcoma Treatment. Bethesda, Md: National Cancer Institute. Date last modified: October 18, 2013. Available at: http://cancer.gov/cancertopics/pdq/treatment/ewings/HealthProfessional. Accessed: March 23, 2014.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Bone cancer. Version 1.2014. Available at: http://www.nccn.org/professionals/physician_gls/pdf/bone.pdf. Accessed March 23, 2014.
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